Tuesday, March 19, 2024
9:00 am - 7:00 pm
Merkin Lobby and Auditorium
Large-scale human genetic studies have succeeded in identifying hundreds of thousands of variants associated with human diseases and traits. One of the grand challenges on the frontier of human genomics and health is to pioneer new scalable paradigms and technologies to systematically link these many variants to cellular programs and gene regulation networks driving complex disorders. This will enable a deep understanding of the genetically-anchored biological programs affected in diseases, lay the foundation for a new generation of rationally designed medicines, and benefit patients and societies across the globe. The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is thrilled to host a symposium highlighting some of the important work and progress ongoing across the vibrant Broad Institute community in this domain. Please join us for an exciting day of science and discussions around this topic.
Co-chaired by Melina Claussnitzer and Kasper Lage
Agenda |
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8:30 - 9:00am |
Registration |
Merkin Lobby |
9:00am - 9:15am |
Welcome Remarks Kasper Lage, Ph.D., M.B.A. |
Broad Auditorium |
9:15am - 9:45am |
Keynote: The future of human genetics Eric Lander, PhD, Founding Director, Core Institute Member |
Broad Auditorium |
9:45am - 10:45am |
Session 1: Technology Development |
Broad Auditorium |
9:45am - 10:15am |
Human brain chimeroids as avatars to study interindividual variation in response to disease risk Paola Arlotta, PhD, Institute member, Departmental Chair and Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University |
Broad Auditorium |
10:15am - 10:45am |
Decoding Cell Fates through Single Cell Genomics, Imaging, and Machine Learning Jian Shu, PhD, Assistant Professor at MGH and Harvard Medical School, Associate Member Broad Institute of MIT and Harvard |
Broad Auditorium |
10:45am - 11:00am |
Break |
Merkin Lobby |
11:00 am - 12:00 pm |
Session 2: Gene Regulation |
Broad Auditorium |
11:00am - 11:30am |
Epigenomics and the regulatory controls of disease Jason Buenrostro, PhD, Assistant Professor at MGH and Harvard Medical School, Associate Member Broad Institute of MIT and Harvard |
Broad Auditorium |
11:30am - 12:00pm |
Linking structure to function in metabolic and blood disorders using Region Capture Micro-C Viraat Goel, PhD Student, Biological Engineering at MIT, lab of Anders Sejr Hansen |
Broad Auditorium |
12:00pm - 1:00pm |
Lunch |
Merkin Lobby |
1:00pm - 2:00pm |
Session 3: From Disease Variants to Cell Function and Cellular Programs |
Broad Auditorium |
1:00pm - 1:30pm |
Variant-to-Function in Obesity Research: Challenges and Opportunities Tune Pers, PhD, Novo Nordisk Foundation Center for Basic Metabolic Research Scientist, Associate Professor at the University of Copenhagen |
Broad Auditorium |
1:30pm - 2:00pm |
Linking genetic variation to actionable therapeutic targets and cellular signatures for cardiometabolic disease Melina Claussnitzer, PhD, Institute Member, Associate Director of Scientific Strategy for the Novo Nordisk Foundation Center, Associate Professor at MGH and Harvard Medical School |
Broad Auditorium |
2:00pm - 2:15pm |
Afternoon Coffee Break |
Merkin Lobby |
2:15pm - 2:45pm |
Defining disease variant function with single cell multimodal sequencing and gene editing Soumya Raychaudhuri, MD, PhD, Institute Member, Director for the Center for Data Sciences at Brigham and Women’s Hospital and Harvard Medical School |
Broad Auditorium |
2:45pm - 3:15pm |
Neuronal modeling and therapeutic profiling of alterations to genome structure and function Michael Talkowski, PhD, Institute Member, Broad Institute; Director, Center for Genomic Medicine, MGH |
Broad Auditorium |
3:15pm - 4:15pm |
Break |
Merkin Lobby |
4:15pm - 5:00pm |
Rapid Fire Presentations |
Broad Auditorium |
5:00pm - 7:00pm |
Poster Session and Reception |
Merkin Lobby |